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KMID : 0387719960070020187
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Korean Journal of Blood Transfusion
1996 Volume.7 No. 2 p.187 ~ p.195
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Cryosupernatant for the Therapeutic Plasma Exchange in Hemolytic Uremic Syndrome-The Characteristics of Home-made Cryosupermatant
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기창석
이우인/김선희/류광현/김대원/오하영
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Abstract
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cryosupernatant which is the residual plasma fraction after removing cryoprecipitate has been used for plasma exchange in thrombotic thrombocytopenic purpura and hemolytic uremic syndrome replacing the fresh frozen plasma. Recently, the unusually
large
von Willebrand factor multimers (UL vWFM) has been observed in patients with refractory or chronic relapsing hemolytic uremic syndrome as well as thrombotic thrombocytopenic purpura which disappeared by infusion or plasma exchange with
cryosupernatant,
and infusion of fresh frozen plasma. The largest multimers of von Willebrand factor were replenished that it might be a cause of refractoriness. This sutudy was conducted to investigate the characteristics of home-made cryosupernatant from thawed
fresh
frozen plasma and its therapeutic effect in a hemolytic uremic syntdrome patient. The level of fibrinogen. Coagulation factor Ⅷ, vWF antigen, and ristocetin cofactor activity was decreased and von Willebrand factor multimers were barely seen in
cryosupernatant than those of in fresh frozen plasma.
A hemolytic uremic syndrome patient tried with exchange and infusion of cryosupernatant showed excellent recovery. It is concluded that home-made cryosupernatant shares many of the features of fresh frozen plasma except factor Ⅷ, especially von
Willebrand factor multimers, and thus it could be a useful alternative to fresh frozen plasma in case of refractory hemolytic uremic syndrome.
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KEYWORD
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